Referrals Clinical Trials Department Newsletter Additional Links
 Patient Care
 Neurosurgery Research
  (BTRC) Brain Tumor Research Center
  Aghi Laboratory
  Alvarez-Buylla Laboratory
  Bankiewicz Laboratory
  Berger Laboratory
  Bergers Laboratory
  Cha Laboratory
  Clinical Neuro-Oncology Research
  Costello Laboratory
  Gupta Laboratory
  Haas-Kogan Laboratory
  Hodgson Laboratory
  Kunwar Laboratory
  Lal Laboratory
  Parsa Laboratory
  Pieper Laboratory
  Weiss Laboratory
  Wiencke Laboratory
  Wrensch Laboratory
  Program Project Grant
  SPORE Grant Projects
  PBTF Grant Projects
  PLGA Grant Projects
  (BASIC) Brain and Spinal Injury Center
  Cerebrovascular Research
  Epilepsy Research
  Movement Disorders Research
  Pain Research
  Pediatric Clinical Research
  Tissue Bank
  Research Core Facility
  Guidelines on Research Data and Reports
 General Information
 Administrative Resources
Home > Neurosurgery Research > BTRC > Wrensch Epidemiology Group  
Wrensch Epidemiology Group
Principal Investigator: Margaret R. Wrensch PhD
Current Research Project
Genetic and Molecular Epidemiology of Adult Glioma
Principal Investigator: Margaret R. Wrensch PhD
Co-Investigators: John Wiencke PhD; Marion Lee PhD; Kenneth Aldape MD; Alex McMillan PhD; Joseph Wiemels PhD; Rei Miike MPH; Karl Kelsey PhD; Gerald DeLorenze PhD; Charles Quesenberry PhD; Allan Bernstein MD; Adriana Weinberg MD; Geoffrey Barger MD
The ongoing study compares case individuals diagnosed with glioma to unaffected individuals. The original and continuing studies 1) test hypotheses that case individuals' relatives are more likely than controls' relatives to have had cancer, brain tumor, and/or certain nervous system conditions; 2) evaluate the contributions of shared environmental exposures or cultural practices to familial cancer clustering; 3) test specific genetic models of inherited susceptibility to disease in cases families; and 4) compare familial, demographic, and environmental risk factors in case and control individuals. During this third cycle, we aim to enhance understanding of genetic, environmental, and immunologic factors associated with adult glioma. We intend to: 1) refine homogeneity of astrocytic cases according to possible etiologic subclasses through genetic and immunohistochemical (IHC) classification of five important tumor markers (p53, EGFR, MDM2, p14arf and p16), and 2) assess associations of brain cancer with a) polymorphisms for a variety of genes involved in DNA repair, detoxification of oxidative and other carcinogenic agents, and immune responses, b) antibodies to varicella zoster virus, other herpes viruses and several allergens, and c) other risk factors obtained through interview including personal history of specific infections and allergies, dietary and other exposures to antioxidants and carcinogenic agents, family history, and other factors.
UCSF UCSF Medical Center UCSF School of Medicine