Selected Publications

Brain Cancer

• Hadaczek, P., Mirek, H., Berger, M. S., and Bankiewicz, K., 2005.
  Limited efficacy of gene transfer in herpes simplex virus-thymidine kinase/ganciclovir gene therapy for brain tumors. J Neurosurg 102, 328-335
• Krauze, M. T., Noble, C. O., Kawaguchi, T., Drummond, D., Kirpotin, D. B., Yamashita, Y., Kullberg, E., Forsayeth, J., Park, J. W., and Bankiewicz, K. S., 2007.
  Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts. Neuro Oncol 9, 393-403
• Noble, C. O., Krauze, M. T., Drummond, D. C., Yamashita, Y., Saito, R., Berger, M. S., Kirpotin, D. B., Bankiewicz, K. S., and Park, J. W., 2006.
  Novel nanoliposomal CPT-11 infused by convection-enhanced delivery in intracranial tumors: pharmacology and efficacy. Cancer Res 66, 2801-2806
• Saito, R., Bringas, J., Mirek, H., Berger, M. S., and Bankiewicz, K. S., 2004.
  Invasive phenotype observed in 1,3-bis(2-chloroethyl)-1-nitrosourea-resistant sublines of 9L rat glioma cells: a tumor model mimicking a recurrent malignant glioma. J Neurosurg 101, 826-831
• Saito, R., Bringas, J. R., Panner, A., Tamas, M., Pieper, R. O., Berger, M. S., and Bankiewicz, K. S., 2004.
  Convection-enhanced delivery of tumor necrosis factor-related apoptosis-inducing ligand with systemic administration of temozolomide prolongs survival in an intracranial glioblastoma xenograft model. Cancer Res 64, 6858-6862
• Saito, R., Krauze, M. T., Noble, C. O., Drummond, D. C., Kirpotin, D. B., Berger, M. S., Park, J. W., and Bankiewicz, K. S., 2006.
  Convection-enhanced delivery of Ls-TPT enables an effective, continuous, low-dose chemotherapy against malignant glioma xenograft model. Neuro Oncol 8, 205-214
• Sampson, J. H., Akabani, G., Friedman, A. H., Bigner, D., Kunwar, S., Berger, M. S., and Bankiewicz, K. S., 2006.
  Comparison of intratumoral bolus injection and convection-enhanced delivery of radiolabeled antitenascin monoclonal antibodies. Neurosurg Focus 20, E14
• Yamashita, Y., Krauze, M. T., Kawaguchi, T., Noble, C. O., Drummond, D. C., Park, J. W., and Bankiewicz, K. S., 2007.
  Convection-enhanced delivery of a topoisomerase I inhibitor (nanoliposomal topotecan) and a topoisomerase II inhibitor (pegylated liposomal doxorubicin) in intracranial brain tumor xenografts. Neuro Oncol 9, 20-28

Medicinal Delivery to the Brain

• Dickinson, PJ, LeCouteur RA, Higgins RJ, Bringas JR, Roberts B, Larson, RF, Yamashita, Y, Krauze, MT, Noble, CO, Drummond, D, Kirpotin, DB, Park, JW, Mitchel S Berger, MB, Bankiewicz KS., 2008.
  Convection enhanced delivery of liposomes containing CPT-11 monitored with real time magnetic resonance imaging in a canine large animal model system. Journal of Neurosurgery (in press).
• Varenika V, Dickinson P, Bringas J, LeCouteur R, Higgins R, Park J, Fiandaca MS, Berger M, Sampson J and Bankiewicz KS., 2008.
  Real-Time Imaging of CED in the Brain Permits Detection of Infusate Leakage. Journal of Neurosurgery (in press).
• Bankiewicz, K. S., Bringas, J., Pivirotto, P., Kutzscher, E., Nagy, D., and Emborg, M. E., 2000.
  Technique for bilateral intracranial implantation of cells in monkeys using an automated delivery system. Cell Transplant 9, 595-607
• Cunningham, J., Oiwa, Y., Nagy, D., Podsakoff, G., Colosi, P., and Bankiewicz, K. S., 2000.
  Distribution of AAV-TK following intracranial convection-enhanced delivery into rats. Cell Transplant 9, 585-594
• Fiandaca, M. S., Forsayeth, J. R., Dickinson, P. J., and Bankiewicz, K. S., 2008.
  Image-guided convection-enhanced delivery platform in the treatment of neurological diseases. Neurotherapeutics 5, 123-127
• Hadaczek, P., Kohutnicka, M., Krauze, M. T., Bringas, J., Pivirotto, P., Cunningham, J., and Bankiewicz, K., 2006.
  Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain. Hum Gene Ther 17, 291-302
• Hadaczek, P., Mirek, H., Bringas, J., Cunningham, J., and Bankiewicz, K., 2004.
  Basic fibroblast growth factor enhances transduction, distribution, and axonal transport of adeno-associated virus type 2 vector in rat brain. Hum Gene Ther 15, 469-479
• Hadaczek, P., Yamashita, Y., Mirek, H., Tamas, L., Bohn, M. C., Noble, C., Park, J. W., and Bankiewicz, K., 2006.
  The "perivascular pump" driven by arterial pulsation is a powerful mechanism for the distribution of therapeutic molecules within the brain. Mol Ther 14, 69-78
• Hamilton, J. F., Morrison, P. F., Chen, M. Y., Harvey-White, J., Pernaute, R. S., Phillips, H., Oldfield, E., and Bankiewicz, K. S., 2001.
  Heparin coinfusion during convection-enhanced delivery (CED) increases the distribution of the glial-derived neurotrophic factor (GDNF) ligand family in rat striatum and enhances the pharmacological activity of neurturin. Exp Neurol 168, 155-161
• Kim, J. H., Auerbach, J. M., Rodriguez-Gomez, J. A., Velasco, I., Gavin, D., Lumelsky, N., Lee, S. H., Nguyen, J., Sanchez-Pernaute, R., Bankiewicz, K., and McKay, R., 2002.
  Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 418, 50-56
• Krauze, M. T., Forsayeth, J., Park, J. W., and Bankiewicz, K. S., 2006.
  Real-time imaging and quantification of brain delivery of liposomes. Pharm Res 23, 2493-2504
• Krauze, M. T., McKnight, T. R., Yamashita, Y., Bringas, J., Noble, C. O., Saito, R., Geletneky, K., Forsayeth, J., Berger, M. S., Jackson, P., Park, J. W., and Bankiewicz, K. S., 2005.
  Real-time visualization and characterization of liposomal delivery into the monkey brain by magnetic resonance imaging. Brain Res Brain Res Protoc 16, 20-26
• Krauze, M. T., Saito, R., Noble, C., Bringas, J., Forsayeth, J., McKnight, T. R., Park, J., and Bankiewicz, K. S., 2005.
  Effects of the perivascular space on convection-enhanced delivery of liposomes in primate putamen. Exp Neurol 196, 104-111
• Krauze, M. T., Saito, R., Noble, C., Tamas, M., Bringas, J., Park, J. W., Berger, M. S., and Bankiewicz, K., 2005.
  Reflux-free cannula for convection-enhanced high-speed delivery of therapeutic agents. J Neurosurg 103, 923-929
• Krauze, M. T., Vandenberg, S. R., Yamashita, Y., Saito, R., Forsayeth, J., Noble, C., Park, J., and Bankiewicz, K. S., 2007.
  Safety of real-time convection-enhanced delivery of liposomes to primate brain: A long-term retrospective. Exp Neurol
• Mamot, C., Nguyen, J. B., Pourdehnad, M., Hadaczek, P., Saito, R., Bringas, J. R., Drummond, D. C., Hong, K., Kirpotin, D. B., McKnight, T., Berger, M. S., Park, J. W., and Bankiewicz, K. S., 2004.
  Extensive distribution of liposomes in rodent brains and brain tumors following convection-enhanced delivery. J Neurooncol 68, 1-9
• Nguyen, J. B., Sanchez-Pernaute, R., Cunningham, J., and Bankiewicz, K. S., 2001.
  Convection-enhanced delivery of AAV-2 combined with heparin increases TK gene transfer in the rat brain. Neuroreport 12, 1961-1964
• Qureshi, N. H., Bankiewicz, K. S., Louis, D. N., Hochberg, F. H., Chiocca, E. A., and Harsh, G. R. t., 2000.
  Multicolumn infusion of gene therapy cells into human brain tumors: technical report. Neurosurgery 46, 663-668; discussion 668-669
• Saito, R., Bringas, J. R., McKnight, T. R., Wendland, M. F., Mamot, C., Drummond, D. C., Kirpotin, D. B., Park, J. W., Berger, M. S., and Bankiewicz, K. S., 2004.
  Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging. Cancer Res 64, 2572-2579
• Saito, R., Krauze, M. T., Bringas, J. R., Noble, C., McKnight, T. R., Jackson, P., Wendland, M. F., Mamot, C., Drummond, D. C., Kirpotin, D. B., Hong, K., Berger, M. S., Park, J. W., and Bankiewicz, K. S., 2005.
  Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol 196, 381-389
• Saito, R., Krauze, M. T., Noble, C. O., Tamas, M., Drummond, D. C., Kirpotin, D. B., Berger, M. S., Park, J. W., and Bankiewicz, K. S., 2006.
  Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: implications for local drug delivery. J Neurosci Methods 154, 225-232
• Sanftner, L. M., Sommer, J. M., Suzuki, B. M., Smith, P. H., Vijay, S., Vargas, J. A., Forsayeth, J. R., Cunningham, J., Bankiewicz, K. S., Kao, H., Bernal, J., Pierce, G. F., and Johnson, K. W., 2005.
  AAV2-mediated gene delivery to monkey putamen: evaluation of an infusion device and delivery parameters. Exp Neurol 194, 476-483

Parkinson's Disease

• Eberling JL, Jagust WJ, Christine CW, Starr P, Larson P, Bankiewicz KS, and Michael J. Aminoff MJ., 2008.
  Results from a Phase I Safety Trial of hAADC Gene Therapy for Parkinson’s Disease. Neurology (in press).
• Bankiewicz, K. S., Daadi, M., Pivirotto, P., Bringas, J., Sanftner, L., Cunningham, J., Forsayeth, J. R., and Eberling, J. L., 2006
  Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys. Exp Neurol 197, 363-372
• Bankiewicz, K. S., Eberling, J. L., Kohutnicka, M., Jagust, W., Pivirotto, P., Bringas, J., Cunningham, J., Budinger, T. F., and Harvey-White, J., 2000.
  Convection-enhanced delivery of AAV vector in parkinsonian monkeys; in vivo detection of gene expression and restoration of dopaminergic function using pro-drug approach. Exp Neurol 164, 2-14
• Bankiewicz, K. S., Forsayeth, J., Eberling, J. L., Sanchez-Pernaute, R., Pivirotto, P., Bringas, J., Herscovitch, P., Carson, R. E., Eckelman, W., Reutter, B., and Cunningham, J., 2006.
  Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC. Mol Ther 14, 564-570
• D'Costa, J., Harvey-White, J., Qasba, P., Limaye, A., Kaneski, C. R., Davis-Warren, A., Brady, R. O., Bankiewicz, K. S., Major, E. O., and Arya, S. K., 2003.
  HIV-2 derived lentiviral vectors: gene transfer in Parkinson's and Fabry disease models in vitro. J Med Virol 71, 173-182
• Eberling, J. L., Cunningham, J., Pivirotto, P., Bringas, J., Daadi, M. M., and Bankiewicz, K. S., 2003.
  In vivo PET imaging of gene expression in Parkinsonian monkeys. Mol Ther 8, 873-875
• Eberling, J. L., Pivirotto, P., Bringas, J., and Bankiewicz, K. S., 2000.
  Tremor is associated with PET measures of nigrostriatal dopamine function in MPTP-lesioned monkeys. Exp Neurol 165, 342-346
• Emborg, M. E., Tetrud, J. W., Moirano, J., McLaughlin, W. W., and Bankiewicz, K. S., 2003.
  Rest tremor in rhesus monkeys with MPTP-induced parkinsonism. Front Biosci 8, a148-154
• Fiandaca, M., Forsayeth, J., and Bankiewicz, K., 2008.
  Current status of gene therapy trials for Parkinson's disease. Exp Neurol 209, 51-57
• Forsayeth, J. R., Eberling, J. L., Sanftner, L. M., Zhen, Z., Pivirotto, P., Bringas, J., Cunningham, J., and Bankiewicz, K. S., 2006.
  A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys. Mol Ther 14, 571-577
• Goldstein, D. S., Li, S. T., Holmes, C., and Bankiewicz, K., 2003.
  Sympathetic innervation in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine primate model of Parkinson's disease. J Pharmacol Exp Ther 306, 855-860
• Oiwa, Y., Eberling, J. L., Nagy, D., Pivirotto, P., Emborg, M. E., and Bankiewicz, K. S., 2003.
  Overlesioned hemiparkinsonian non human primate model: correlation between clinical, neurochemical and histochemical changes. Front Biosci 8, a155-166
• Oiwa, Y., Sanchez-Pernaute, R., Harvey-White, J., and Bankiewicz, K. S., 2003.
  Progressive and extensive dopaminergic degeneration induced by convection-enhanced delivery of 6-hydroxydopamine into the rat striatum: a novel rodent model of Parkinson disease. J Neurosurg 98, 136-144
• Sanchez-Pernaute, R., Harvey-White, J., Cunningham, J., and Bankiewicz, K. S., 2001.
  Functional effect of adeno-associated virus mediated gene transfer of aromatic L-amino acid decarboxylase into the striatum of 6-OHDA-lesioned rats. Mol Ther 4, 324-330
• Sanchez-Pernaute, R., Studer, L., Bankiewicz, K. S., Major, E. O., and McKay, R. D., 2001.
  In vitro generation and transplantation of precursor-derived human dopamine neurons. J Neurosci Res 65, 284-288