UCSF Neurological Surgery faculty since 2004
 
Read about Dr. Wrensch's current research
 
Dr. Wrensch is investigating the genetic and molecular epidemiology of adult brain cancer as principal investigator of the ongoing population-based case-control San Francisco Bay Area Adult Glioma Study. She is also Principal Investigator of one of the Department's four Specialized Program of Research Execllence (SPORE) grant projects. In future research projects she plans to continue categorization of molecular pathology of tumors according to presence or absence of p53 modifications and other genetic alterations in efforts to define more etiologically homogeneous subgroups.
 
Education, Training, and Previous Positions
 
1971: BSc, Ohio State University
1973: MSc, Ohio State University
1977: MPH, University of California, Berkeley
1983: PhD, University of California, Berkeley
1985-1986: Assistant Research Epidemiologist, UCSF
1986-present: Assistant Professor, Associate Professor, Professor, Department of Epidemiology and Biostatistics, UCSF
1993-1995: Chief, Division of Epidemiology at the Parnassus Campus, UCSF
2001: Interim Head, Cancer Epidemiology Division, UCSF
2001-present: Adjunct Investigator, Kaiser Permanente, Division of Research, Oakland, CA
 
Selected Professional Memberships and Appointments
 
Society for Epidemiologic Research
American Association for Cancer Research
Society of Neuro-Oncology
Southwest Oncology Group, Brain Committee
 
Selected Honors and Awards
 
1976-1980: Public Health Service trainee
1980-1982: National Cancer Institute trainee
1980-1982: Grossman Endowment recipient
1994: Nominated, Excellence in Small Group Teaching, UCSF
2000: Society of Neuro-oncology/American Brain Tumor Foundation Award for Excellence in Epidemiology, 5th Annual Meeting
2003: Marin Breast Cancer Watch, Community Breast Cancer Research Award
2003: Susan Love MD Breast Cancer Foundation, Otto W. Sartorius, MD Award for Excellence in Research
 
Contact
 
Margaret R. Wrensch MPH, PhD
University of California San Francisco
Department of Neurological Surgery
Department of Epidemiology and Biostatistics
San Francisco, California 94143-1215
Phone: (415) 476-1979
 
Selected Recent Publications
 
Keegan TH, Chang ET, John EM, Horn-Ross PL, Wrensch MR, Glaser SL, Clarke CA. Recent changes in breast cancer incidence and risk factor prevalence in San Francisco Bay Area and California women: 1988-2004. Breast Cancer Res 2007;9(5):R62 [Epub ahead of print].
 
Malmer B, Adatto P, Armstrong G, Barnholtz-Sloan J, Bernstein JL, Claus E, Davis F, Houlston R, Il'yasova D, Jenkins R, Johansen C, Lai R, Lau C, McCarthy B, Nielsen H, Olson SH, Sadetzki S, Shete S, Wiklund F, Wrensch M, Yang P, Bondy M. GLIOGENE an International Consortium to Understand Familial Glioma. Cancer Epidemiol Biomarkers Prev 2007;16(9):1730-4.
 
Felini MJ, Olshan AF, Schroeder JC, North KE, Carozza SE, Kelsey KT, Liu M, Rice T, Wiencke JK, Wrensch MR. DNA repair polymorphisms XRCC1 and MGMT and risk of adult gliomas. Neuroepidemiology 2007;29(1-2):55-8.
 
Wiemels JL, Wiencke JK, Kelsey KT, Moghadassi M, Rice T, Urayama KY, Miike R, Wrensch M. Allergy-related polymorphisms influence glioma status and serum IgE levels. Cancer Epidemiol Biomarkers Prev 2007;16(6):1229-35.
 
Hansen HM, Wiemels JL, Wrensch M, Wiencke JK. DNA quantification of whole genome amplified samples for genotyping on a multiplexed bead array platform. Cancer Epidemiol Biomarkers Prev 2007;16(8):1686-90.
 
Claus EB, Black PM, Bondy ML, Calvocoressi L, Schildkraut JM, Wiemels JL, Wrensch M. Exogenous hormone use and meningioma risk: what do we tell our patients? [Review] Cancer 2007;110(3):471-6.
 
Gupta N, Park J, Solomon C, Kranz DA, Wrensch M, Wu YW. Long-term outcomes in patients with treated childhood hydrocephalus. J Neurosurg 2007;106(5 Suppl):334-9.
 
Fisher JL, Schwartzbaum JA, Wrensch M, Wiemels JL. Epidemiology of brain tumors [Review]. Neurol Clin 2007;25(4):867-90, vii.
 
Wu Y, Green NL, Wrensch MR, Zhao S, Gupta N. Ventriculoperitoneal shunt complications in California: 1990 to 2000. Neurosurgery 2007;61(3):557-63.
 
Wiencke JK, Zheng S, Jelluma N, Tihan T, Vandenberg S, Tamguney T, Baumber R, Parsons R, Lamborn KR, Berger MS, Wrensch MR, Haas-Kogan DA, Stokoe D. Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro Oncol 2007;9(3):271-9.
 
Wrensch M, Wiencke JK, Wiemels J, Miike R, Patoka J, Moghadassi M, McMillan A, Kelsey KT, Aldape K, Lamborn KR, Parsa AT, Sison JD, Prados MD. Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival. Cancer Res 2006;66(8):4531-41.
 
Fisher JL, Schwartzbaum JA, Wrensch M, Berger MS. Evaluation of epidemiologic evidence for primary adult brain tumor risk factors using evidence-based medicine [Review]. Prog Neurol Surg 2006;19:54-79.
 
Wrensch M, Kelsey KT, Liu M, Miike R, Moghadassi M, Sison JD, Aldape K, McMillan A, Wiemels J, Wiencke JK. ERCC1 and ERCC2 polymorphisms and adult glioma. Neuro Oncol 2005;7(4):495-507.
 
Schwartzbaum JA, Fisher JL, Aldape KD, Wrensch M. Epidemiology and molecular pathology of glioma [Review]. Nat Clin Pract Neurol 2006;2(9):494-503.
 
Tedeschi-Blok N, Lee M, Sison JD, Miike R, Wrensch M. Inverse association of antioxidant and phytoestrogen nutrient intake with adult glioma in the San Francisco Bay Area: a case-control study. BMC Cancer 2006;6:148.
 
Wrensch M, Rice T, Miike R, McMillan A, Lamborn KR, Aldape K, Prados MD. Diagnostic, treatment, and demographic factors influencing survival in a population-based study of adult glioma patients in the San Francisco Bay Area. Neuro Oncol 2006;8(1):12-26.
 
Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM. Epidemiology of intracranial meningioma [Review]. Neurosurgery 2005;57(6):1088-95.
 
Tang J, Shao W, Dorak MT, Li Y, Miike R, Lobashevsky E, Wiencke JK, Wrensch M, Kaslow RA, Cobbs CS. Positive and negative associations of human leukocyte antigen variants with the onset and prognosis of adult glioblastoma multiforme. Cancer Epidemiol Biomarkers Prev 2005;14(8):2040-4.
 
Krishnan G, Felini M, Carozza SE, Miike R, Chew T, Wrensch M. Occupation and adult gliomas in the San Francisco Bay Area. J Occup Environ Med 2003;45:639-47.