UCSF Neurological Surgery faculty since 2003
 
Dr. VandenBerg researches the invasive motility of reactive and neoplastic astrocytes, with a focus on the coordinate interactions of growth factors and integrin activation in regulating invasive tumor cell growth using monolayer and three-dimensional matrix cultures systems. His interests in translational diagnostic research are aimed at the characterization of new prognostic markers of biologic behavior and therapeutic responses for diffuse-type astrocytomas, using a combination of genomic and proteomic techniques. His clinical interests focus on the diagnostic classification of CNS tumors using histopathologic, immunohistochemical, and molecular morphologic techniques.
 
Selected Professional Memberships and Appointments
American Association of Neuropathologists
American Society for Cell Biology
American Society for Investigative Pathology
Society for Neuroscience
 
Selected Honors and Awards
 
1997-2000: Chair, Program Committee, American Society for Investigative Pathology
2000-2004: ASIP representative, Experimental Biology Board
2003-2004: Vice-President, American Association of Neuropathologists
 
Contact
 
Scott VandenBerg MD, PhD
University of California, San Francisco
Department of Pathology
513 Parnassus Ave. HSE 722 Box 0511
San Francisco, CA 94143
Phone: (415) 502-7796
 
Selected Recent Publications
 
Baia GS, Dinca EB, Ozawa T, Kimura ET, McDermott MW, James CD, Vandenberg SR, Lal A. An Orthotopic Skull Base Model of Malignant Meningioma. Brain Pathol 2007; [Epub ahead of print].
 
Carvalho LH, Smirnov I, Baia GS, Modrusan Z, Smith JS, Jun P, Costello JF, McDermott MW, Vandenberg SR, Lal A. Molecular signatures define two main classes of meningiomas. Mol Cancer 2007;6:64.
 
Lim DA, Cha S, Mayo MC, Chen MH, Keles E, VandenBerg S, Berger MS. Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype. Neuro Oncol 2007;9(4):424-9.
 
Entin-Meer M, Yang X, VandenBerg SR, Lamborn KR, Nudelman A, Rephaeli A, Haas-Kogan DA. In vivo efficacy of a novel histone deacetylase inhibitor in combination with radiation for the treatment of gliomas. Neuro Oncol 2007;9(2):82-8.
 
Yoo H, Baia GS, Smith JS, McDermott MW, Bollen AW, Vandenberg SR, Lamborn KR, Lal A. Expression of the hypoxia marker carbonic anhydrase 9 is associated with anaplastic phenotypes in meningiomas. Clin Cancer Res 2007;13(1):68-75.
 
Wiencke JK, Zheng S, Jelluma N, Tihan T, Vandenberg S, Tamguney T, Baumber R, Parsons R, Lamborn KR, Berger MS, Wrensch MR, Haas-Kogan DA, Stokoe D. Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. Neuro Oncol 2007;9(3):271-9.
 
Cadieux B, Ching TT, VandenBerg SR, Costello JF. Genome-wide hypomethylation in human glioblastomas associated with specific copy number alteration, methylenetetrahydrofolate reductase allele status, and increased proliferation. Cancer Res 2006;66(17):8469-76.
 
Jackson EL, Garcia-Verdugo JM, Gil-Perotin S, Roy M, Quinones-Hinojosa A, VandenBerg S, Alvarez-Buylla A. PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 2006;51(2):187-99.
 
Baia GS, Slocum AL, Hyer JD, Misra A, Sehati N, VandenBerg SR, Feuerstein BG, Deen DF, McDermott MW, Lal A. A genetic strategy to overcome the senescence of primary meningioma cell cultures. J Neurooncol 2006;78(2):113-21.
 
Swerdlow RH, Redpath GT, Binder DR, Davis JN 2nd, VandenBerg SR. Mitochondrial DNA depletion analysis by pseudogene ratioing. J Neurosci Methods 2006;150(2):265-71.
 
Entin-Meer M, Rephaeli A, Yang X, Nudelman A, VandenBerg SR, Haas-Kogan DA. Butyric acid prodrugs are histone deacetylase inhibitors that show antineoplastic activity and radiosensitizing capacity in the treatment of malignant gliomas. Mol Cancer Ther 2005;4(12):1952-61.
 
Ozawa T, Britz GW, Kinder DH, Spence AM, VandenBerg S, Lamborn KR, Deen DF, Berger MS. Bromophenol blue staining of tumors in a rat glioma model. Neurosurgery 2005;57(5):1041-7.
 
Salasznyk RM, Westcott AM, Klees RF, Ward DF, Xiang Z, Vandenberg S, Bennett K, Plopper GE. Comparing the protein expression profiles of human mesenchymal stem cells and human osteoblasts using gene ontologies. Stem Cells Dev 2005;14(4):354-66.