UCSF Neurological Surgery faculty since 1990
 
Read about Dr. Noble's current research
 
Dr. Noble focuses on the neurobiology of traumatic injury to the central nervous system. The extent of functional recovery after traumatic brain or spinal cord injury is not simply the consequence of the initial mechanical destruction of tissue, but is also attributed to the evolution of complex secondary events that contribute to early and delayed cell injury. The Noble laboratory employs experimental models of traumatic brain and spinal cord injury in the rodent to study the early events that contribute to cell injury and impair functional recovery. Researchers are focused on the role of the blood-brain and spinal-cord barriers in early pathogenesis after traumatic injury, the acute and chronic influences of inflammation on both injury and repair mechanisms, and the identification of those cellular defense mechanisms, intrinsic to the brain and spinal cord, that protect against secondary injury and may be essential for limiting the extent of cell injury. These studies are funded by the National Institutes of Health.  
 
Education, Training, and Previous Positions
 
1975: BS, University of Utah
1975-76: Physical Therapist, Cedars-Sinai Medical Center, Los Angeles
1977-78: Physical Therapist, University of California Medical Center, Los Angeles
1982: PhD, University of California at Los Angeles
1982-83: Instructor, Department of Anatomy, University of Maryland, Baltimore
1983-85: Research Associate, Department of Anatomy, Georgetown University
1985-90: Assistant Research Neuroanatomist, Neurology Department, UCSF
1990-93: Assistant Professor, Neurological Surgery, UCSF
1993-99: Associate Professor, Neurological Surgery, UCSF
2000-present: Professor, Neurological Surgery, UCSF
 
Selected Professional Memberships and Appointments
 
Society for Neuroscience
American Association of Anatomists
Society for Neurotrauma
Editorial Board: Journal of Neurotrauma
Editorial Board: International Journal of Neuroprotection and Neuroregeneration
 
Contact
 
Linda J. Noble PhD
University of California San Francisco
521 Parnassus Avenue, Room C224
San Francisco, CA 94143-0520
(415) 476-4850
 
Selected Recent Publications
 
Boyd BS, Puttlitz C, Noble-Haeusslein LJ, John CM, Trivedi A, Topp KS. Deviations in gait pattern in experimental models of hindlimb paresis shown by a novel pressure mapping system. J Neurosci Res 2007;85(10):2272-83.
 
Lin Y, Vreman HJ, Wong RJ, Tjoa T, Yamauchi T, Noble-Haeusslein LJ. Heme oxygenase-1 stabilizes the blood-spinal cord barrier and limits oxidative stress and white matter damage in the acutely injured murine spinal cord. J Cereb Blood Flow Metab 2007;27(5):1010-21.
 
Igarashi T, Potts MB, Noble-Haeusslein LJ. Injury severity determines Purkinje cell loss and microglial activation in the cerebellum after cortical contusion injury. Exp Neurol 2007;203(1):258-68.
 
Pullela R, Raber J, Pfankuch T, Ferriero DM, Claus CP, Koh SE, Yamauchi T, Rola R, Fike JR, Noble-Haeusslein LJ. Traumatic injury to the immature brain results in progressive neuronal loss, hyperactivity and delayed cognitive impairments. Dev Neurosci 2006;28(4-5):396-409.
 
Rola R, Mizumatsu S, Otsuka S, Morhardt DR, Noble-Haeusslein LJ, Fishman K, Potts MB, Fike JR. Alterations in hippocampal neurogenesis following traumatic brain injury in mice. Exp Neurol 2006;202(1):189-99.
 
Olivas AD, Noble-Haeusslein LJ. Phospholipase A2 and spinal cord injury: a novel target for therapeutic intervention. Ann Neurol 2006;59(4):577-9.
 
Potts MB, Koh SE, Whetstone WD, Walker BA, Yoneyama T, Claus CP, Manvelyan HM, Noble-Haeusslein LJ. Traumatic injury to the immature brain: inflammation, oxidative injury, and iron-mediated damage as potential therapeutic targets. NeuroRx 2006;3(2):143-53.
 
Trivedi AA, Igarashi T, Compagnone N, Fan X, Hsu JY, Hall DE, John CM, Noble-Haeusslein LJ. Suitability of allogeneic sertoli cells for ex vivo gene delivery in the injured spinal cord. Exp Neurol 2006;198(1):88-100.
 
McLean CW, Mirochnitchenko O, Claus CP, Noble-Haeusslein LJ, Ferriero DM. Overexpression of glutathione peroxidase protects immature murine neurons from oxidative stress. Dev Neurosci 2005;27(2-4):169-75.
 
Chang EF, Claus CP, Vreman HJ, Wong RJ, Noble-Haeusslein LJ. Heme regulation in traumatic brain injury: relevance to the adult and developing brain [Review]. J Cereb Blood Flow Metab 2005;25(11):1401-17.