UCSF Neurological Surgery faculty since 2006
 
Dr. Beattie has been interested in the neural mechanisms of recovery after brain and spinal cord injury for many years. He and his wife and collaborator, Dr. Jacqueline Bresnahan (also a member of the Neurosurgery faculty), have recently moved their laboratory to the Brain and Spinal Injury Center (BASIC) at UCSF from Ohio State University. Their group is known for developing preclinical models to study recovery of function after spinal cord injury, and for studies of the biology of neural injury and repair. Current projects include analyses of the interrelationship of post-injury inflammatory events and excitotoxic cell death, the roles of oligodendrocyte death and replacement in recovery after injury, and the development of stem and progenitor cell transplantation strategies for promoting recovery after spinal cord injury. The laboratory continues to develop new animal paradigms for modeling human neurotrauma. BASIC's location at the SFGH along with the physician-scientists of UCSF Neurotrauma program will promote basic and clinical science interactions, and new animal models will be generated based on knowledge of current treatments and outcomes in the human neurotrauma arena. For example, there is an emerging interest in post injury edema, studied in rodents using high field MR imaging. Acute studies of interventions that can reduce edema in animal studies may be taken directly to clinical studies in the neurotrauma ICU. Dr. Beattie's goal is to help translate the laboratory's expertise in the biology of injury and recovery to treatments that can be implemented and tested in neurotrauma patients at SFGH and other centers
 
Education, Training, and Previous Positions
 
1972: BS, University of California, Davis
1974: MA, Ohio State University
1977: PhD, Ohio State University
1977-1978: NIH Postdoctoral Fellow in Neuropsychology/Neuroanatomy, Ohio State University
1978-1979: Postdoctoral (?) Neuroanatomy, Michigan State University
1979-1985: Assistant Professor, Neurosurgery and Anatomy, Ohio State University
1985-1992: Associate Professor, Neurosurgery, Neurobiology, Anatomy and Cell Biology, Ohio State University
1992-1999: Professor, Neurosurgery, Neurobiology, Anatomy and Cell Biology, Ohio State University
1999-2002: Professor and Interim Chair, Neuroscience, Ohio State University
2002-2006: Professor and Chair, Neuroscience, Ohio State University
 
Selected Professional Memberships and Appointments
 
Society for Neuroscience
National Neurotrauma Society
International Neurotrauma Society (Founding Member)
Inernational Society for Stem Cell Research
 
Selected Honors and Awards
 
1979: National Research Service Award, Individual NIH Fellowship
1994: Knight Lecture in Neuroscience, University of Miami
1997: Rudolf Magnus Lecture, Utrecht University
2000: John D. and E. Olive Brumbaugh Chair of Brain Research and Teaching
 
Contact
 
Michael S. Beattie PhD
University of California, San Francisco
Brain and Spinal Injury Center
1001 Potrero Avenue, Bldg 1, Room 101
San Francisco, CA 94114
Phone: (415) 206-3859
E-mail: michael.beattie@ucsf.edu
 
Selected Recent Publications
 
Miller BA, Crum JM, Tovar CA, Ferguson AR, Bresnahan JC, Beattie MS. Developmental stage of oligodendrocytes determines their response to activated microglia in vitro. J Neuroinflammation 2007;4:28.
 
Nout YS, Bresnahan JC, Culp E, Tovar CA, Beattie MS, Schmidt MH. Novel technique for monitoring micturition and sexual function in male rats using telemetry. Am J Physiol Regul Integr Comp Physiol 2007;292(3):R1359-67.
 
Christensen RN, Ha BK, Sun F, Bresnahan JC, Beattie MS. Kainate induces rapid redistribution of the actin cytoskeleton in ameboid microglia. J Neurosci Res 2006;84(1):170-81.
 
Gensel JC, Tovar CA, Hamers FP, Deibert RJ, Beattie MS, Bresnahan JC. Behavioral and histological characterization of unilateral cervical spinal cord contusion injury in rats. J Neurotrauma 2006;23(1):36-54.
 
Miller BA, Sun F, Christensen RN, Ferguson AR, Bresnahan JC, Beattie MS. A sublethal dose of TNFalpha potentiates kainate-induced excitotoxicity in optic nerve oligodendrocytes. Neurochem Res 2005;30(6-7):867-75.
 
Beattie MS. Inflammation and apoptosis: linked therapeutic targets in spinal cord injury. Trends Mol Med 2004;10(12):580-3.
 
Hill CE, Proschel C, Noble M, Mayer-Proschel M, Gensel JC, Beattie MS, Bresnahan JC. Acute transplantation of glial-restricted precursor cells into spinal cord contusion injuries: survival, differentiation, and effects on lesion environment and axonal regeneration. Exp Neurol 2004;190(2):289-310.
 
Beattie MS, Harrington AW, Lee R, Kim JY, Boyce SL, Longo FM, Bresnahan JC, Hempstead BL, Yoon SO. ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron 2002;36(3):375-86.
 
Beattie EC, Stellwagen D, Morishita W, Bresnahan JC, Ha BK, Von Zastrow M, Beattie MS, Malenka RC. Control of synaptic strength by glial TNFalpha. Science. 2002 Mar 22;295(5563):2282-5.
 
Crowe MJ, Bresnahan JC, Shuman SL, Masters JN, Beattie MS. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 1997;3(1):73-6. Erratum in: Nat Med 1997;3(2):240.