UCSF Neurological Surgery faculty since 1998
 
Read about Dr. Bankiewicz's current research
 
Dr. Bankiewicz's research focus is restorative interventions, specifically drug delivery and gene transfer, in models of Parkinson's disease and brain tumors. His laboratory studies delivery of therapeutic agents into the central nervous system through automated cell-implantation, convection-enhanced and gene transfer-based delivery methods, as well as in vivo applications of MRI and PET to detect in-vivo changes in brain and their correlation with functional outcome.
 
For the past 12 years, Dr. Bankiewicz has managed his own research group, comprising laboratory technicians, postdoctoral fellows, undergraduate students, and sabbatical visitors. He has trained over 15 postdoctoral fellows and has been involved in many fruitful collaborative projects. His academic teaching has been devoted to training of residents, postdoctoral fellows, and graduate students. He holds several patents, including those for use of neuro-derived fetal cell lines for transplantation therapy, convection-enhanced delivery of adeno-associated virus (AAV) vectors, and convection-enhanced delivery of AAV viral vector with AADC for the treatment of Parkinson's disease.
 
Education, Training, and Previous Positions
 
1983: MD, Jagielonian University, Crakow, Poland
1983-1984: Internship in General Surgery, Medical Academy of Warsaw, Poland
1983-1985: Resident, Neuroorthopedic Postgraduate Medical Center, Warsaw, Poland
1983-1985: Assistant Professor, Post-graduate Medical Center, Warsaw, Poland
1985-1988: Visiting Fellow, Surgical Neurology Branch, NINDS, NIH, Bethesda, MD
1988-1991: Visiting Associate Scientist, Surgical Neurology Branch, NINDS, NIH, Bethesda, MD
1991-1992: Visiting Scientist, Surgical Neurology Branch. NINDS, NIH, Bethesda, MD
1991-1993: Chief, Central Nervous System (CNS) Implantation Unit, Surgical Neurology Branch, NINDS, NIH Bethesda, MD
1992-1993: Special Volunteer, Surgical Neurology Branch, NINDS, NIH, Bethesda, MD
1992-1997: Chief, Preclinical Studies, Somatix Therapy Corporation, Alameda, CA
1994-1997: Director, Division of CNS Implantation and Regeneration, The Parkinson's Institute, Sunnyvale, CA
1994-1998: Visiting Scientist, Laboratory for Functional Imaging, Lawrence Berkeley National Laboratory
1996: PhD, Institute of Neurology and Psychiatry, Warsaw, Poland
1997-2001: Acting Chief, Molecular Therapeutics Section, NINDS, NIH, Bethesda, MD
 
Selected Honors and Awards
 
1985: Fogarty Fellowship, National Institutes of Health, Bethesda, Maryland
1999: Patent Award, NINDS, NIH, Bethesda, Maryland
2000: Special Act or Service Award, NINDS, NIH, Bethesda, Maryland
2002: Drug Development Prize, Academy of Molecular Imaging
 
Contact
 
Krys Bankiewicz MD, PhD
University of California, San Francisco
Neurosurgery Department, Mission Center Building
1855 Folsom Street, Room 230
San Francisco, CA 94103
Phone: 415-502-3132
Email: kbank@itsa.ucsf.edu
 
Selected Recent Publications
 
Fiandaca MS, Forsayeth JR, Dickinson PJ, Bankiewicz KS. Image-guided convection-enhanced delivery platform in the treatment of neurological diseases. Neurotherapeutics 2008;5(1):123-7.
 
Fiandaca M, Forsayeth J, Bankiewicz K. Current status of gene therapy trials for Parkinson's disease. Exp Neurol 2008;209(1):51-57.
 
Krauze MT, Noble CO, Kawaguchi T, Drummond D, Kirpotin DB, Yamashita Y, Kullberg E, Forsayeth J, Park JW, Bankiewicz KS. Convection-enhanced delivery of nanoliposomal CPT-11 (irinotecan) and PEGylated liposomal doxorubicin (Doxil) in rodent intracranial brain tumor xenografts. Neuro Oncol 2007;9(4):393-403.
 
Kawaguchi T, Yamashita Y, Kanamori M, Endersby R, Bankiewicz KS, Baker SJ, Bergers G, Pieper RO. The PTEN/Akt pathway dictates the direct alphaVbeta3-dependent growth-inhibitory action of an active fragment of tumstatin in glioma cells in vitro and in vivo. Cancer Res 2006;66(23):11331-40.
 
Yamashita Y, Krauze MT, Kawaguchi T, Noble CO, Drummond DC, Park JW, Bankiewicz KS. Convection-enhanced delivery of a topoisomerase I inhibitor (nanoliposomal topotecan) and a topoisomerase II inhibitor (pegylated liposomal doxorubicin) in intracranial brain tumor xenografts. Neuro Oncol 2007;9(1):20-8.
 
Bankiewicz KS, Forsayeth J, Eberling JL, Sanchez-Pernaute R, Pivirotto P, Bringas J, Herscovitch P, Carson RE, Eckelman W, Reutter B, Cunningham J. Long-term clinical improvement in MPTP-lesioned primates after gene therapy with AAV-hAADC. Mol Ther 2006;14(4):564-70.
 
Forsayeth JR, Eberling JL, Sanftner LM, Zhen Z, Pivirotto P, Bringas J, Cunningham J, Bankiewicz KS. A dose-ranging study of AAV-hAADC therapy in Parkinsonian monkeys. Mol Ther 2006;14(4):571-7.
 
Hadaczek P, Kohutnicka M, Krauze MT, Bringas J, Pivirotto P, Cunningham J, Bankiewicz K. Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain. Hum Gene Ther 2006;17(3):291-302.
 
Noble CO, Krauze MT, Drummond DC, Yamashita Y, Saito R, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW. Novel nanoliposomal CPT-11 infused by convection-enhanced delivery in intracranial tumors: pharmacology and efficacy. Cancer Res 2006;66(5):2801-6.
 
Saito R, Krauze MT, Noble CO, Tamas M, Drummond DC, Kirpotin DB, Berger MS, Park JW, Bankiewicz KS. Tissue affinity of the infusate affects the distribution volume during convection-enhanced delivery into rodent brains: Implications for local drug delivery. J Neurosci Methods 2006; [Epub ahead of print].
 
Daadi MM, Pivirotto P, Bringas J, Cunningham J, Forsayeth J, Eberling J, Bankiewicz KS. Distribution of AAV2-hAADC-transduced cells after 3 years in Parkinsonian monkeys. Neuroreport 2006;17(2):201-4.
 
Bankiewicz KS, Daadi M, Pivirotto P, Bringas J, Sanftner L, Cunningham J, Forsayeth JR, Eberling JL. Focal striatal dopamine may potentiate dyskinesias in parkinsonian monkeys. Exp Neurol 2006;197(2):363-72.
 
Hadaczek P, Kohutnicka M, Krauze MT, Bringas J, Pivirotto P, Cunningham J, Bankiewicz K. Convection-enhanced delivery of adeno-associated virus type 2 (AAV2) into the striatum and transport of AAV2 within monkey brain. Hum Gene Ther 2006;17(3):291-302.
 
Saito R, Krauze MT, Bringas JR, Noble C, McKnight TR, Jackson P, Wendland MF, Mamot C, Drummond DC, Kirpotin DB, Hong K, Berger MS, Park JW, Bankiewicz KS. Gadolinium-loaded liposomes allow for real-time magnetic resonance imaging of convection-enhanced delivery in the primate brain. Exp Neurol 2005;196(2):381-9.