UCSF Neurological Surgery faculty since 2000
 
Read about Dr. Alvarez-Buylla's current research
 
Dr. Alvarez-Buylla has an international reputation for his work in developmental neuroscience and stem-cell neurobiology research. His principal research interests are in the assembly of the brain, brain tumors and repair, and the ontogeny and phylogeny of behavior.
 
His expertise encompasses the fields of developmental biology, developmental neuroscience, neurobiology, molecular and cellular neurobiology, and learning and plasticity. An innovator and inventor as well as a scientist, Dr. Alvarez-Buylla has designed a device for mounting tissue sections on histological slides, a digital stereotaxic apparatus for mice and song birds, a computer-based mapping system for tissue sections, and a fluorescent staining technique.
 
Education, Training, and Previous Positions
 
1978: BSc, Queen's University, Kingston, Canada
1983: Licenciado in Biomedical Research, Universidad Nacional Autonoma de Mexico
1982-1983: Graduate Courses, Universidad Nacional Autonoma de Mexico
1988: PhD, Rockefeller University
1988-1989: Postdoctoral Research, Rockefeller University
1989-1991: Assistant Professor, Rockefeller University
1991-1995: Assistant Professor-Head of Laboratory, Rockefeller University
1995-2000: Associate Professor-Head of Laboratory, Rockefeller University
 
Selected Professional Memberships and Appointments
 
Society for Neuroscience
International Brain Research Organization
Society for Biochemistry
Academia de Ciencias de America Latina (ACAL)
International Society for Stem Cell Research
 
Selected Honors and Awards
 
1981-1982: Undergraduate International Fellowship - Universidad Nacional Autonoma de Mexico (UNAM)
1983: Medal Gavino Barreda- UNAM
1992: Sinsheimer Award
2000: Jacob Javits Award
2002: Neuronal Plasticity Prize. Fondation IPSEN, France. (Shared with Dr. R. McKay and Dr. S. Weiss)
 
Contact
 
Arturo Alvarez-Buylla PhD
University of California, San Francisco
Neurosurgery Research, Box 0520
10 Kirkham St., Room K-127
San Francisco, CA 94143
Phone: (415) 514-2348
 
Selected Recent Publications
 
Han YG, Spassky N, Romaguera-Ros M, Garcia-Verdugo JM, Aguilar A, Schneider-Maunoury S, Alvarez-Buylla A. Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells. Nat Neurosci 2008;11(3):277-84.
 
Jackson EL, Alvarez-Buylla A. Characterization of Adult Neural Stem Cells and Their Relation to Brain Tumors. Cells Tissues Organs 2008; [Epub ahead of print].
 
Ihrie RA, Alvarez-Buylla A. Cells in the astroglial lineage are neural stem cells. Cell Tissue Res 2008;331(1):179-91.
 
Sanai N, Berger MS, Garcia-Verdugo JM, Alvarez-Buylla A. Comment on "Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension". Science 2007;318(5849):393.
 
Merkle FT, Mirzadeh Z, Alvarez-Buylla A. Mosaic organization of neural stem cells in the adult brain. Science 2007;317(5836):381-4.
 
Kohwi M, Petryniak MA, Long JE, Ekker M, Obata K, Yanagawa Y, Rubenstein JL, Alvarez-Buylla A. A subpopulation of olfactory bulb GABAergic interneurons is derived from Emx1- and Dlx5/6-expressing progenitors. J Neurosci 2007;27(26):6878-91.
 
Long JE, Garel S, Alvarez-Dolado M, Yoshikawa K, Osumi N, Alvarez-Buylla A, Rubenstein JL. Dlx-dependent and -independent regulation of olfactory bulb interneuron differentiation. J Neurosci 2007;27(12):3230-43.
 
Lim DA, Huang YC, Alvarez-Buylla A. The adult neural stem cell niche: lessons for future neural cell replacement strategies [Review]. Neurosurg Clin N Am 2007;18(1):81-92.
 
Merkle FT, Alvarez-Buylla A. Neural stem cells in mammalian development. Curr Opin Cell Biol 2006;18(6):704-9.
 
Menn B, Garcia-Verdugo JM, Yaschine C, Gonzalez-Perez O, Rowitch D, Alvarez-Buylla A. Origin of oligodendrocytes in the subventricular zone of the adult brain. J Neurosci 2006;26(30):7907-18.
 
Jackson EL, Garcia-Verdugo JM, Gil-Perotin S, Roy M, Quinones-Hinojosa A, VandenBerg S, Alvarez-Buylla A. PDGFR alpha-positive B cells are neural stem cells in the adult SVZ that form glioma-like growths in response to increased PDGF signaling. Neuron 2006;51(2):187-99.
 
Sawamoto K, Wichterle H, Gonzalez-Perez O, Cholfin JA, Yamada M, Spassky N, Murcia NS, Garcia-Verdugo JM, Marin O, Rubenstein JL, Tessier-Lavigne M, Okano H, Alvarez-Buylla A. New neurons follow the flow of cerebrospinal fluid in the adult brain. Science 2006;311(5761):629-32.
 
Lim DA, Suárez-Fariñas M, Naef F, Hacker CR, Menn B, Takebayashi H, Magnasco M, Patil N, Alvarez-Buylla A. In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis. Mol Cell Neurosci 2006;31(1):131-48.
 
Quiñones-Hinojosa A, Sanai N, Soriano-Navarro M, Gonzalez-Perez O, Mirzadeh Z, Gil-Perotin S, Romero-Rodriguez R, Berger MS, Garcia-Verdugo JM, Alvarez-Buylla A. Cellular composition and cytoarchitecture of the adult human subventricular zone: a niche of neural stem cells. J Comp Neurol 2006;494(3):415-34.
 
Sanai N, Alvarez-Buylla A, Berger MS. Neural stem cells and the origin of gliomas. N Engl J Med 2005;353(8):811-22.